The driver of the pickup truck allegedly ran from the scene and is still being sought by police.
Two people are dead following a wrong-way crash overnight on the Henry Hudson Parkway.
Police said the driver of a pickup truck was traveling south in the northbound lanes just after 2 a.m. Saturday when the truck struck a car near exit 13.
Both men, ages 38 and 40, inside the car were taken to the hospital where they were pronounced dead, according to police.
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Two other cars were hit in the chaos, but the people inside those vehicles were not hurt.
The driver of the pickup truck and a passenger hopped out and ran from the scene. Police said officers caught up to the passenger quickly; he was taken to the hospital to be treated for an ankle injury.
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Police were still looking for the driver by sun-up.
Northbound lanes remained closed for several hours.